Senior Scientist, siRNA Design and Off-Target Analysis

📋 Description

• Senior Scientist in AbbVie's Biotherapeutic and Genetic Medicine (BGM) to support siRNA design and
• Establish and optimize siRNA sequences with enhanced efficacy and reduced off-target liabilities.
• Develop off-target assessment workflows; integrate transcriptomic/genomic data.
• Build ML models using high-throughput siRNA data for sequence selection.
• Collaborate on NGS library prep for off-target analysis and cross-functional translation of
• Prepare reports, presentations, and technical summaries to inform safety assessments.

🎯 Requirements

• BS, MS, or PhD in computational biology, genomics, RNA biology, or related field with 0-12+ years
• Proficiency in Python and/or R; experience building reproducible analytical workflows.
• Experience supporting off-target analysis or risk assessment for siRNA/ASO therapies.
• Strong background in NGS library prep and transcriptomic data analysis.
• Ability to translate transcriptomic findings into biological insights; strong communication and
• Experience preparing scientific/regulatory-facing documentation.

🎁 Benefits

• Competitive compensation range: 109,500 – 208,500 USD/year.
• Comprehensive benefits package including PTO, health/dental/vision, 401(k).
• Eligibility for short-term incentive programs.
• Equal opportunity employer; hybrids of relocation not specified.