Job Description
📋 Description Define and implement reproducible protocols for oligonucleotide conjugates Develop conjugation strategies (cysteine, lysine, glycan, site-specific) Design and incorporate linker chemistries to optimize PKPD Assist in internal lab build and equipment procurement Assist analytical scientists in developing methods (HPLC, MS) Collaborate with protein engineers to prep conjugates for studies 🎯 Requirements BS/MS/PhD in chemistry or protein engineering; 3+ years in conjugates Experience with antibody, protein or peptide conjugates Knowledge of cysteine-maleimide, click chemistry, site-specific Purification and analytical methods: HPLC, SEC, IEX, LCMS Experience with oligonucleotide modalities (siRNA/ASOs) is a plus Strong communicator and able to work independently in a lab 🎁 Benefits Annual bonus eligibility Long-term incentives On-site role at Cambridge, MA
